Dr. Marta Maleszewska’s project – “Exploring DMRTA2 in Glioma: Epigenetic Regulation, Angiogenesis, and Biomarker Development”

14 03 2025

The research project titled “Exploring DMRTA2 in Glioma: Epigenetic Regulation, Angiogenesis, and Biomarker Development” focuses on the role of DMRTA2 in glioblastoma multiforme (GBM), the most aggressive brain tumor. Dr. Maleszewska aims to investigate how DMRTA2 influences angiogenesis (the formation of new blood vessels in the tumor) and how its epigenetic regulation could be utilized in therapy and diagnostics.

A key aspect of this project is the potential development of a liquid biopsy, a non-invasive method for detecting tumor DNA traces in patients’ blood. This innovative approach could significantly improve disease monitoring and treatment strategies. Furthermore, research on DMRTA2 may lead to new therapeutic strategies that disrupt glioblastoma’s ability to resist treatment and enhance drug delivery across the blood-brain barrier.

Dr. Marta Maleszewska is an experienced researcher specializing in epigenetics and brain tumor biology. By utilizing advanced technologies such as CRISPR, 3D tumor models, and next-generation sequencing, she aims to gain deeper insights into glioblastoma progression and identify new therapeutic opportunities.