The project is supported by the Foundation for Polish Science – PARENT-BRIDGE Programme co-financed by the European Union within European Regional Development Fund.
„Analysis of the potential use of Campylobacter jejuni outer membrane vesicles (OMVs) for the immunization of chickens”,
Value of the project: 323180 PLN
Participation of European Union: 274 703 PLN
Duration of the project: March 2013 - June 2015
Principal ivestigator: dr Renata Godlewska
Campylobacter bacteria are the most commonly isolated human enteropathogens, which cause intestinal inflammation often accompanied by long-term, bloody and mucous diarrhea. Economic costs due to patient therapy and work absence are enormous.
In developed countries Campylobacter infections usually occur after consumption of contaminated and improperly prepared poultry meat. Therefore, numerous attempts have been undertaken to design a protective vaccine for chicken in order to lower or eliminate C. jejuni contamination of poultry meat. This, in turn, will unquestionably contribute to limiting the number of infections in humans.
Among factors playing crucial role in the process of pathogenesis of Gram-negative bacteria are outer membrane vesicles (OMV). Examination of their content revealed that virulence factors can constitute even up to half of the proteins present in the vesicles. OMV can carry these molecules into the environment and/or into other bacteria or eukaryotic cells.
The mechanisms of C. jejuni pathogenesis are still far from being fully understood. It seems very likely that vesicles comprise also other proteins engaged in the virulence process.
In our project we would like to conduct the detailed analysis of the C. jejuni OMV composition and factors modulating both vesicle formation and content.
The second aim of the project is using wtOMV and modified OMV for chicken immunization.